An Experimental Model of Pneumonia Induced by Methicillin-resistent Staphylococcus Aureus in Ventilated Piglets
نویسندگان
چکیده
AFFILIATIONS Pneumology Service, Thorax Clinic Institute, Hospital Clinic, IDIBAPS (Institut dInvestigacions Biomèdiques Agustí Pi Sunyer), CIBERES (CIBER de Enfermedades Respiratorias, 06/06/0028), University of Barcelona, Barcelona, Spain; Cardiology Service, Thorax Clinic Institute, Hospital Clinic, Red REDINSCOR RD06/0003/1002, Barcelona, Spain; Pharmacy Service, Hospital Clinic, Barcelona, Spain; CDB, Hospital Clinic, Barcelona, Spain.
منابع مشابه
An experimental model of pneumonia induced by methicillin-resistant Staphylococcus aureus in ventilated piglets.
The objectives of the study were to validate a model of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia in ventilated piglets and to study the time-course of biological markers and histopathological changes. 12 piglets were intubated and inoculated with 15 mL of a suspension of 10(6) colony forming units of MRSA in every lobe through the bronchoscope channel. The piglets were venti...
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Animal models are an essential step between "in vitro" testing and clinical studies. Different animal models have been useful for the study of pathophysiology, diagnosis and therapy in ventilator-associated pneumonia (VAP). Aspiration has been studied in dog and cat models and bacteriological diagnosis has been evaluated in baboons. Pigs have been used for studying either spontaneous or induced...
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RATIONALE Colonization of lower airways by Staphylococcus aureus is a risk factor for the development of ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP). However, little is known about the virulence factors of methicillin-sensitive and -resistant S. aureus (MSSA and MRSA) that may influence host colonization and progression to VAT and VAP. OBJECTIVES We...
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INTRODUCTION A spiration pneumonia in the critically ill ventilated patient is a serious complication of enteral nutrition (EN), but can also occur even in the absence of feedings, such as with the aspiration of endogenous secretions or saliva. This is especially true in patients who have decreased mental status, are unable to protect their airway, and/or are intubated and mechanically ventilat...
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